Melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor RORα

Cashmere is the fine bottom hair produced by secondary follicles of skin. This economically important. Previous studies our research group have shown that exogenous melatonin (MT) can regulate periodic growth follicles, induce development villi, and alter expression some genes related to follicle development. Few on regulation villus MT binding receptors been published. In this study, was implanted subcutaneously behind ear Inner Mongolia cashmere goats. RT-qPCR, in situ hybridization, Western blot analysis, immunofluorescence RNAi techniques were used investigate functions regulating The results showed binds nuclear receptor RORα dermal papilla stimulates promotes growth. mRNA skin goats a trend first increasing then decreasing. began increase February, peaked April, reached lowest level May. significantly affected β- catenin gene, key gene development, presence MT. It will lay solid molecular foundation for further mechanism between achieve artificial time yield improve effect production.